Lactate Testing - Medical Applications

  • Obstetrics
  • Emergency & Critical Care)

 

There are many uses of lactate in healthcare. Some of these are well established, for example lactate measurement in fitness and cardio training. As a world-leader in lactate, EKF has been closely involved in recently developed applications of lactate in obstetric medicine. On this page you can find out more about the increasingly important role of lactate in healthcare.


Lactate and Cardio-training, Weight-reduction and Fitness


Regular endurance exercise has many benefits for health and well-being. It has been proven to lower systolic and diastolic blood pressure, improve insulin sensitivity and lower HbA1c levels, lower triglycerides and increase HDL-cholesterol. Regular power exercise, meanwhile, can increase insulin sensitivity.

The maximal fat oxidation rate is reached under long term aerobic conditions because this is when predominantly free fatty acids are used as the energy source. In contrast, under anaerobic conditions mainly carbohydrates are used for generating energy.

The measurement of lactate during step tests reveals the shift from aerobic (oxygen dependent) to complementary anaerobic (non-oxygen dependent) metabolism. The knowledge of this ‘anaerobic threshold’ can be used for the definition of training intensities and conditions to achieve optimal fitness and weight reduction.

Furthermore, lactate testing can support a secure and efficient training avoiding critical over-exhaustion.


Lactate and Obstetrics

During birth a number of potential complications for mother and child may occur. These complications can lead to decreased oxygenation of the fetus and/or prolonged pain and injury of the mother. Monitoring mother and fetus closely provides decisions tools for an efficient and safe process of birth.

Cord blood lactate (CBL) Umbilical cord blood analysis, including lactate measurement, provides an indication of the acid–base balance of the infant at birth. It is recommended in all high‐risk deliveries and, in some countries, is performed routinely after all deliveries. Cord blood lactate (CBL) has a predictive value for perinatal outcome and elevated lactate levels alert clinicians to undertake immediate intervention.

Fetal scalp lactate (FSL) Monitoring fetal heart rate with a cardiotocograph (CTG) often indicates fetal distress but most of those neonates are not hypoxic at birth. A diagnostic test is required to confirm abnormal CTG values. In 1962 Saling et al / first described the use of pH measurement from fetal scalp during delivery as an indicator of hypoxia.

Measuring pH became a widely used clinical practice based on their findings. This approach is complicated by the need to collect a significant amount of blood (30-50 μl). This has led to reported sampling failure rates of 11-20%.

The alternative to this approach, fetal scalp lactate (FSL), is a simpler test which requires only a low volume of blood. Studies report significantly fewer failures in sampling with lactate analysis and no differences in short term neonatal outcome.



Emergency Medicine and Critical Care

There are a number of causes for hyperlactatemia in critical ill patients. Sepsis, shock and trauma are the most common and serious ones. Pre-hospital measurements of lactate have been shown to improve the prediction of mortality, surgery and multi-organ failure.


Please Note: Lactate Scout+ can be used as a monitoring or screening tool by qualified staff in various medical settings. The test results should only be used as a support for clinical decision making. As with any chemical reaction, the user must be aware of the potential effect on the result due to unknown interference from medication or endogenous substances. All patient results must be evaluated considering the total clinical status of the patient. Any decision for medical use of the device must be taken by the responsible clinician based on the specification of the device and local regulatory guidelines.